Manufacturing / Industrial • Inspections

Cyclotron Targetry Maintenance OP.0005

The purpose of this document is to provide the process for performing and reviewing of cyclotron target maintenance. Specifically, to ensure that the targets and associated components have been maintained, documents have been reviewed, and all actions were completed within designated timelines.

2 MX Main Demo

02/03/2023

Cyclotron Targetry Maintenance OP.0005

Purpose / Scope: The purpose of this document is to provide the process for performing and reviewing of cyclotron target maintenance. Specifically, to ensure that the targets and associated components have been maintained, documents have been reviewed, and all actions were completed within designated timelines.

Responsible: The site cyclotron engineer, and/ or personnel from the Technical Service Group (TSG), or responsible designee, is responsible for maintaining the cyclotron targets and associated components according to procedure. Site QA/QAS shall be responsible for understanding and verifying that this procedure is in place to assure conformance with the requirements stated herein. QA/QAS is responsible for verifying/reviewing that maintenance was completed. The site Facility Manager is responsible for ensur

Schedule: Every in-use target shall receive periodic maintenance not to exceed every three (3) months, i.e., quarterly. This should be documented on Attachment 3, Cyclotron Targetry Preventive Maintenance Record.

Equipment / Materials:

Equipment

Materials

QTY

SP #

Procedure:

A. Instructions

1. In-use cyclotron targets are to be maintained as needed, not to exceed quarterly (i.e., every 3 months).

a. Follow the work instructions in Attachment 1, Cyclotron Targetry Work Instructions.

2. In the event that the Target Insert does not come clean after multiple cleaning cycles, a soda blasting procedure may be employed.

a. Follow the work instructions in Attachment 2, Soda Blasting Procedure for Cleaning Target Inserts.

B. Documentation

1. Use Attachment 3, Cyclotron Targetry Preventive Maintenance Record (or other suitable and validated electronic system) to document PM instances on each target.

a. Attachment 3 is to be printed by the site cyclotron engineer (or personnel from the Operational Service Group or responsible designee) at the beginning of each quarter.
b. Line out and N/A unused spaces per QA.0014, Good Documentation Practices.
c. At the end of each quarter provide completed log to QA/QAS for review.
d. Multiple logs may be utilized if the site is equipped with more than 6 targets per cyclotron.

2. Targets that are out of service or not in use in the given quarter do not need to receive quarterly PM.

3. A change control is not required to update the work instructions (Attachment 1 and 2) in this procedure unless the procedure will also be updated. Control of Attachments will be tracked via the document signature approval process and by update number. It is recommended that the originator be a member of TSG.

Document Originator & Reviewer Approval Signatures:

Approval

Name

Title

Signature

Click here to sign

Date

Schedule:

Every in-use target shall receive periodic maintenance as needed, not to exceed every three (3) months, i.e., quarterly.

Equipment / Materials:

Equipment

Rebuild Parts List

Part Name

Part #

QTY

Materials

QTY

SP #

Work Instructions

Overview: The target and components will be sonicated in solvents that must be used in specific order. The normal sequence is to disassemble the target, sonicate in acetone, followed by alcohol, followed by tw0 (2) sonications in HPLC water. Time constraints may dictate that some solvents be omitted but the two (2) sonications in HPLC water MUST always be performed. Choloroform is only to be used in badly contaminated targets and this should be an extremely rare occurrence. Rinsing the beaker and compo

A. GE BTI Target

CAUTION: Target is highly radioactive until Target Window removed. When Target Window is removed, immediately place in a sufficiently shielded location!

1. Place the Target in Maintenance Fixture or equivalent behind sufficient radiation shielding.

2. Disassemble the Target.

a. When Target Window is exposed, quickly remove it from either the target insert (usually stuck here) or on the Front Flange and quickly transfer radioactive window to an appropriate storage container for decay.
b. Remove all eleven (11) O-rings and store in suitable waste container. While not as radioactive as the window, they should be stored in a shielded area.
c. While still radioactive, the levels are low enough to allow work to be done on a bench with minimal shielding.

c. While still radioactive, the levels are low enough to allow work to be done on a bench with minimal shielding.

NOTE: Do NOT let solvent boil off which will leave a hard residue on the insert.

 Take care that no water from the Sonicator gets into the beaker; either from splashing or dripping off the Sonicator top. Aluminum foil or a seal such as a glove should be used to keep solvents from evaporating and contamination from the water in the sonicator.

 When an emergency rebuild or a quick rebuild is necessary, the Acetone rinse can be eliminated, and the sonicating times reduced.

 Note any & all observations in Logbook

a. Inspect Target Insert

i. Inspect Insert for any sign of damage such as beam hitting rear of target chamber, scratches in O-ring grooves, etc. ii. Inspect rear of insert to make sure there is no debris or anything that could restrict cooling water flow. Remove debris.
iii. Document any damage or anything else out ordinary; ideally take photographs

b. Clean Target Insert and Stainless-Steel nipples in an Ultrasonic Bath with Acetone heated to ~40°C (100⁰F) for an appropriate time; minimally, ~10 min*. Upon completion, inspect liquid. It should be clear. If not, repeat the step. If, after couple of rounds, the liquid is still not clear, the insert probably needs to be blasted with sodium bicarbonate. (See Attachment 2)

c. ** Clean Target Insert, SS Nipples, Target Window, and 023 & 007 O-rings with Alcohol heated to ~40°C (100°F) for an appropriate time; minimally, ~10 min*; to remove any residual acetone left on the surface of the insert.

i. NOTE: Target Window, 023 O-Ring, & 007 O-rings may also be cleaned by just wiping them off using alcohol

d. Allow time for any residual Alcohol to evaporate before rinsing

e. ** sonicate Target Insert, SS Nipples, Window, and 023 & 007 O-rings in High Purity water heated to ~40°C (100°F) for an appropriate time; minimally, ~10 min*. This step MUST be repeated at least minimum of two (2) sonication’s in HPLC water.

f. Remove parts from water and place clean parts on an absorbent surface and allow to dry.

*Suggested but NOT required time. ** If using a single beaker, thoroughly clean the beaker between each step and rinse with next liquid. If using multiple beakers, rinse each beaker with the liquid it will contain.

4. Reassemble Target

a. Reassemble target in Maintenance Fixture
i. Care should be taken to make sure nothing gets on Target Window such as fingerprints, grease, oils, etc.
ii. Stainless-Steel Nipples should be installed lastly after the rest of the assembled Target is assembled iii. Make sure the Stainless-Steel nipples are installed in the correct orientation. iv. When installing the Stainless-Steel nipples, be sure to tighten them down evenly; relative to each other and individually.

5. Install target on Accelerator

a. Replace Silicon O-Ring (-212) in target flange
b. Install the target back on the Cyclotron. Do NOT open Beam Exit Valve. c. Pressure Test Target

NOTE: NEVER connect the target to the cooling system until pressure testing has been completed. There is potential to pressurize the water cooing system with helium if there is a leak.

6. Perform a test/conditioning bombardment

7. Record all work done in Logbook

8. Record the date that the target was rebuilt using Attachment 3.

B. IBA 18/9 BTI Target

CAUTION: Target is highly radioactive until Target Window removed. When Target Window is removed, immediately place is a sufficiently shielded location!!

1. Place the Target in Maintenance Fixture or equivalent behind sufficient radiation Shielding.

2. Disassemble Target.

a. When Target Window is exposed, quickly remove it from either the target insert (usually stuck here) or on the Front Flange and quickly transfer radioactive window to an appropriate storage container for decay.
b. Remove all Twelve (12) O-rings and store in suitable waste container. While not as radioactive as the window, they should be stored in a shielded area.
c. While still radioactive, the levels are low enough to allow work to be done on a bench with minimal shielding.

3. Cleaning Target Insert & components

NOTE: Do NOT let solvent boil off which will leave a hard residue on the insert

 Take care that no water from the Sonicator gets into the beaker either from splashing or dripping off the Sonicator top. Aluminum foil or a seal such as a glove should be used to keep solvents from evaporating and contamination from the water in the sonicator.

 When an emergency rebuild or a quick rebuild being necessary, the Acetone rinse can be eliminated, and the sonicating times reduced.

 Note all observations in Logbook

4. Inspect Target Insert

5. Inspect Insert for any sign of damage such as beam hitting rear of target chamber, scratches in O-ring grooves, etc.

6. Inspect rear of insert to make sure there is no debris or anything that could restrict cooling water flow. Remove any debris.

7. Document any damage or anything else out ordinary; ideally take photograph

8. **Clean Target Insert and Stainless-Steel nipples in an Ultrasonic Bath with Acetone heated to ~40°C (100°F) for an appropriate time; minimally, ~ 10 min*. Upon completion, inspect liquid. It should be clear. If not, repeat the step. If, after couple of rounds, the liquid is still not clear, the insert probably needs to be blasted with sodium bicarbonate.

9. ** Clean Target Insert, SS Nipples, Target Window, and 029 & 006 O-rings in heated Alcohol to ~40°C (100°F) for an appropriate time; minimally, ~10 min* to remove any residual acetone left on the surface of the insert.

i. NOTE: Target Window, 029 O-Ring, & 006 O-ring can be cleaned by just wiping them off using alcohol
b. Allow time for any residual Alcohol to evaporate before rinsing
c. Rinse Target Insert, SS Nipples, Window, and 029 & 006 O-rings in High Purity water heated to ~40⁰C (100⁰F) for an appropriate time; minimally, ~10 min*. This step MUST be repeated at least minimum of two (2) sonication’s in HPLC water.
d. Upon completion, remove parts from water and place clean parts on an absorbent surface to dry

*Suggested but NOT required time **If using a single beaker, thoroughly clean the beaker between each step and rinse with next liquid. If using multiple beakers, rinse each beaker with the liquid it will contain.

10. Reassemble Target

a. Reassemble target in Maintenance Fixture
i. Care should be taken to make sure nothing gets on Target Window such as fingerprints, grease, oils, etc.
ii. Stainless-Steel Nipples should be installed lastly after the rest of the assembled Target is assembled iii. Make sure the Stainless-Steel nipples are installed in the correct orientation.
iv. When installing the Stainless-Steel nipples, be sure to tighten them down evenly; relative to each other and individually
1. NOTE: The Stainless-Steel nipples MUST be installed last, or it will damage both the insert and the nipples.
b. Pressure Test the target
i. If the target is to be placed in service immediately, in addition to pressure testing, connect the water cooling lines and check for cooling water leaks prior to opening the beam exit valves.

11. Install Target on Cyclotron replacing any O-ring seals necessary.

12. Perform a test bombardment

13. Record all work done in Logbook

14. Record the date that the target was rebuilt using Attachment 3.

C. Cyclotope Target

CAUTION: Target is highly radioactive until Target Window removed. When Target Window is removed, immediately place it in a sufficiently shielded location!!

1. Place the Target in Maintenance Fixture or equivalent behind sufficient radiation Shielding.

2. Disassemble Target.

a. When Windows are exposed, quickly remove them from the assembly and quickly transfer the highly radioactive windows to an appropriate shielded storage container for decay
b. Remove all O-rings; three (3) on the Front Flange assembly, two (2) from the Helium Cooling Flange assembly, two (2) on the Target Insert & window, and three (3) on the Water-Cooling Cap assembly at the rear of the target. While not as radioactive as the windows, they should be stored in a properly shielded container.
c. Inspect O-ring surfaces and grooves for any sign of damage i.e., scratches, foreign material, etc. Clean all surfaces & O-ring grooves.
d. Inspect Insulating washers for Front Flange for any sign of damage. If ANY damage, replace washer
e. Clean all O-ring, windows, sealing surfaces by wiping with Methanol. After cleaning, place clean parts on an absorbent surface and allow to dry.

3. Cleaning Target Chamber

NOTE: Do NOT let solvents boil off which will leave a hard residue in the Target Chamber

 Take care that no water from Sonicator gets into the beaker either from splashing or dripping off the Sonicator Top. Aluminum foil or a seal such as a glove should be used to keep the solvents from evaporating and contamination from the water in the sonicator.

 When an emergency or a quick rebuild is necessary, the Acetone rinse can be eliminated, and the sonicating times reduced.

 Note ALL observation in Logbook.

a. Inspect Target Chamber

i. Inspect Insert for any sign of damage such as beam hitting rear of the target chamber, scratches on the Oring sealing surfaces, etc.
ii. Inspect the rear of the insert to make sure there is no debris or anything that could restrict cooling water flow. Remove any debris.
iii. Document any damage or anything else out of the ordinary.

b. **Clean Target Chamber in an Ultrasonic Bath with Acetone heated to ~40⁰C (100⁰F) for an appropriate time; typically, ~10 min*. Upon completion, inspect liquid. It should be clear, if not, repeat step. If after a couple of rounds, the liquid is still not clear, the chamber needs to be blasted with sodium bicarbonate (See Attachment

c. **Clean Target Chamber, Target window, & 022 Buna-N O-ring in heated Alcohol to ~40⁰C (100⁰F) for an appropriate time; minimally, ~10 min* to remove any residual acetone left on the insert

NOTE: Target Window & 022 Buna-N O-ring can be cleaned by just wiping them off using alcohol

d. Allow time for any residual alcohol or evaporate before rinsing

e. ** Sonicate Target Chamber, Target Window and 022 Buna-N O-ring in High Purity Water heated to ~40⁰C (100⁰F) for an appropriate time; minimally , ~10 min*. This step must be repeated at least once-minimum of 2 sonications in HPLC Water

f. Upon completion, remove parts from water and place on clean sheet of low lint paper or cloth and allowed to dry.

*Suggested but NOT required time. ** If using a single beaker, thoroughly clean the beaker between each step and rinse with next liquid. If using multiple beakers, rinse each beaker with the liquid it will contain.

4. Reassemble Target

a. Care should be taken to make sure nothing gets on windows such as fingerprints, grease, oils, etc.
b. 022 Buna-N O-ring is installed as seal between the Target Window and the Target Insert
c. Prior to installing, inspect Insulating washers for any sign of damage. Replace insulating washer if there is any sign of damage.
d. Tighten all bolts down evenly
e. Check the electrical insulation between the Target plug and the target body
f. Pressure test target body to at least 300 psi increasing the pressure in small steps. Leak rate must be less than

Attachment Approval Signatures:

Approval

Name

Title

Signature

Click here to sign

Date

Revision & Update History:

Revision

Issue Date

Reference #

Details of Change

Schedule:

THIS IS NOT ROUTINE MAINTENANCE. This procedure will be followed when required when the target insert does not clean up under the normal procedure (OP.0005, Cyclotron Targetry Maintenance).

Equipment / Materials:

Equipment

Materials

QTY

SP #

IMPORTANT NOTICE: The abrasive blasting equipment must ONLY have been used with Sodium Bicarbonate. ANY PREVIOUS MATERIALS RUN THROUGH BLASTER WILL RUIN THE INSERT.

Section #16

Work Instructions

A. Soda Blast Procedure

Note: If target is extremely contaminated or still has the presence of radioactive isotopes, sonicate in acetone for at least 10 min.

1. Make sure target insert is dry and move to blasting cabinet.
2. Blast with abrasive the interior of the insert in the cabinet.
NOTE: This is a slow process. The media is not overly aggressive, and it can take considerable time (15+ minutes) to affect the burned area. Do not expect immediate results. Take your time and focus the blasting stream on the back of the interior chamber of the target. The burn mark may not completely disappear but should show changes in darkness. Focus on the damaged area and keep the blast nozzle moving slowly.
3. DO NOT blast the sealing surfaces (O-ring grooves)
4. After sufficient abrasive blasting, blow remaining media out of target with dry compressed air, focusing on making sure ALL water channels are free from blasting media.
5. Rinse target insert at least twice for a minimum of 10 minutes each in high purity water to remove all residual sodium bicarbonate.
6. Clean the target insert per procedure
NOTE: During the clean, repeat the HPLC water rinse so have at least two (2) water rinses.
7. Record work in Cyclotron Logbook

Schedule: Every in-use target shall receive periodic maintenance not to exceed every three (3) months, i.e., quarterly. This should be documented on Attachment 3, Cyclotron Targetry Preventive Maintenance Record.

Equipment / Materials:

Equipment

Materials

QTY

SP #

Procedure:

A. Instructions

1. In-use cyclotron targets are to be maintained as needed, not to exceed quarterly (i.e., every 3 months).

a. Follow the work instructions in Attachment 1, Cyclotron Targetry Work Instructions.

2. In the event that the Target Insert does not come clean after multiple cleaning cycles, a soda blasting procedure may be employed.

a. Follow the work instructions in Attachment 2, Soda Blasting Procedure for Cleaning Target Inserts.

B. Documentation

1. Use Attachment 3, Cyclotron Targetry Preventive Maintenance Record (or other suitable and validated electronic system) to document PM instances on each target.

a. Attachment 3 is to be printed by the site cyclotron engineer (or personnel from the Operational Service Group or responsible designee) at the beginning of each quarter.

b. Line out and N/A unused spaces per QA.0014, Good Documentation Practices.

c. At the end of each quarter provide completed log to QA/QAS for review.

d. Multiple logs may be utilized if the site is equipped with more than 6 targets per cyclotron.

2. Targets that are out of service or not in use in the given quarter do not need to receive quarterly PM.

Document Originator & Reviewer Approval Signatures:

Approval

Name

Title

Signature

Date

Schedule:

Every in-use target shall receive periodic maintenance as needed, not to exceed every three (3) months, i.e., quarterly.

Equipment / Materials:

Equipment

Rebuild Parts List

Part Name

Part #

QTY

Materials

Materials

QTY

SP #

Work Instructions

A. GE BTI Target

CAUTION: Target is highly radioactive until Target Window removed. When Target Window is removed, immediately place in a sufficiently shielded location!

1. Place the Target in Maintenance Fixture or equivalent behind sufficient radiation shielding.

2. Disassemble the Target.

a. When Target Window is exposed, quickly remove it from either the target insert (usually stuck here) or on the Front Flange and quickly transfer radioactive window to an appropriate storage container for decay.

b. Remove all eleven (11) O-rings and store in suitable waste container. While not as radioactive as the window, they should be stored in a shielded area.

c. While still radioactive, the levels are low enough to allow work to be done on a bench with minimal shielding.

c. While still radioactive, the levels are low enough to allow work to be done on a bench with minimal shielding.

NOTE: Do NOT let solvent boil off which will leave a hard residue on the insert.

 Take care that no water from the Sonicator gets into the beaker; either from splashing or dripping off the Sonicator top. Aluminum foil or a seal such as a glove should be used to keep solvents from evaporating and contamination from the water in the sonicator.

 When an emergency rebuild or a quick rebuild is necessary, the Acetone rinse can be eliminated, and the sonicating times reduced.

 Note any & all observations in Logbook

a. Inspect Target Insert

i. Inspect Insert for any sign of damage such as beam hitting rear of target chamber, scratches in O-ring grooves, etc. ii. Inspect rear of insert to make sure there is no debris or anything that could restrict cooling water flow. Remove debris.

iii. Document any damage or anything else out ordinary; ideally take photographs

c. ** Clean Target Insert, SS Nipples, Target Window, and 023 & 007 O-rings with Alcohol heated to ~40°C (100°F) for an appropriate time; minimally, ~10 min*; to remove any residual acetone left on the surface of the insert.

i. NOTE: Target Window, 023 O-Ring, & 007 O-rings may also be cleaned by just wiping them off using alcohol

d. Allow time for any residual Alcohol to evaporate before rinsing

e. ** sonicate Target Insert, SS Nipples, Window, and 023 & 007 O-rings in High Purity water heated to ~40°C (100°F) for an appropriate time; minimally, ~10 min*. This step MUST be repeated at least minimum of two (2) sonication’s in HPLC water.

f. Remove parts from water and place clean parts on an absorbent surface and allow to dry.

*Suggested but NOT required time. ** If using a single beaker, thoroughly clean the beaker between each step and rinse with next liquid. If using multiple beakers, rinse each beaker with the liquid it will contain.

4. Reassemble Target

a. Reassemble target in Maintenance Fixture

i. Care should be taken to make sure nothing gets on Target Window such as fingerprints, grease, oils, etc.

5. Install target on Accelerator

a. Replace Silicon O-Ring (-212) in target flange

b. Install the target back on the Cyclotron. Do NOT open Beam Exit Valve. c. Pressure Test Target

NOTE: NEVER connect the target to the cooling system until pressure testing has been completed. There is potential to pressurize the water cooing system with helium if there is a leak.

6. Perform a test/conditioning bombardment

7. Record all work done in Logbook

8. Record the date that the target was rebuilt using Attachment 3.

B. IBA 18/9 BTI Target

CAUTION: Target is highly radioactive until Target Window removed. When Target Window is removed, immediately place is a sufficiently shielded location!!

1. Place the Target in Maintenance Fixture or equivalent behind sufficient radiation Shielding.

2. Disassemble Target.

a. When Target Window is exposed, quickly remove it from either the target insert (usually stuck here) or on the Front Flange and quickly transfer radioactive window to an appropriate storage container for decay.

b. Remove all Twelve (12) O-rings and store in suitable waste container. While not as radioactive as the window, they should be stored in a shielded area.

c. While still radioactive, the levels are low enough to allow work to be done on a bench with minimal shielding.

3. Cleaning Target Insert & components

NOTE: Do NOT let solvent boil off which will leave a hard residue on the insert

 Take care that no water from the Sonicator gets into the beaker either from splashing or dripping off the Sonicator top. Aluminum foil or a seal such as a glove should be used to keep solvents from evaporating and contamination from the water in the sonicator.

 When an emergency rebuild or a quick rebuild being necessary, the Acetone rinse can be eliminated, and the sonicating times reduced.